PUBLICATIONS
Lab members are underlined; † and * denotes equal contribution and corresponding respectively.
One-step flow synthesis of size-controlled polymer nanogels in a fluorocarbon microfluidic chip
Reynaldo Carlos K. Montalbo, Meng-Jie Wu and Hsiung-Lin Tu*
RSC Advances 2024,14, 11258-11265. https://doi.org/10.1039/D4RA01956C |
TNFR1 mediates heterogeneity in single-cell NF-κB activation
Chieh-Teng Cheng, Jye-Chian Hsiao, Alexander Hoffmann and Hsiung-Lin Tu*
iScience 2024, 27 (4), 109486. https://doi.org/10.1016/j.isci.2024.109486 |
Structural Variants and Ultralow Detection Ability for Tryptamine in Two Polymorphs of a Zincophosphite Framework
Mu-Chien Yin†, Pi-Chen Wei†, Ying Li†, Todd Hsu†, Jia-Yi Jian, Kai-Chi Chang, Ching-Ping Lu, Hsiung-Lin Tu* and Chih-Min Wang*
Inorganic Chemistry 2023, 62, 18150-18156. (Supplementary Cover) https://pubs.acs.org/doi/10.1021/acs.inorgchem.3c02620 |
Innovative Real-Time Flow Sensor Using Detergent-Free Complex Emulsions with Dual-Emissive Semi-Perfluoroalkyl Substituted α-Cyanostilbene
Narani Rakesh†, Hsiung-Lin Tu†, Po-Chun Chang, Sofani Tafesse Gebreyesus, Che-Jen Lin*
Advanced Science, 2023, 10, 2304108. https://doi.org/10.1002/advs.202304108 |
Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection
Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang* and Hsiung-Lin Tu*
ACS Sensors, 2023, 8, 2263-2270 (Supplementary Cover). https://doi.org/10.1021/acssensors.3c00228 |
DNA tension assays reveal that force-dependent integrin activation regulates neurite outgrowth in primary cortical neurons
Ying-Chi Chen, Ying Li, Ching-Cher Sanders Yan, Chao-Ping Hsu, Pei-Lin Cheng* and Hsiung-Lin Tu*
Biomaterials Advances 2023, 150, 213431. https://doi.org/10.1016/j.bioadv.2023.213431 |
Recent advances in microfluidics for single-cell functional proteomics
Sofani Gebreyesus†, Gul Muneer†, Chih-Cheng Huang†, Asad Siyal, Mihir Anand, Yu-Ju Chen and Hsiung-Lin Tu*
Lab on a Chip 2023, 23, 1726-1751. https://doi.org/10.1039/D2LC01096H |
Liposome-based artificial cells: From gene expression to reconstitution of cellular functions and phenotypes
Samuel Herianto, Po-Jen Chien, Ja-an Annie Ho and Hsiung-Lin Tu*
Biomaterials Advances 2022, 142, 213156. https://doi.org/10.1016/j.bioadv.2022.213156 |
Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment
Chen Chen, Chien-Hsin Chu, Ying Chu, Ting-Ya Chang, Sheng-Wen Chen, Shu-Yang Liang, Yun-Chi Tsai, Bi-Chang Chen, Hsiung-Lin Tu and Pei-Lin Cheng*
Cell Reports, 2022, 40 (7), 111188. https://doi.org/10.1016/j.celrep.2022.111188 |
Chip assisted formation of phase-separated liposomes for reconstituting spatial protein–lipid interactions
Po-Jen Chien, Yi-Lun Shih, Chieh-Teng Cheng and Hsiung-Lin Tu*
Lab Chip, 2022, 22, 2540-2548. https://doi.org/10.1039/D2LC00089J |
Surface viscosity‐dependent neurite initiation in cortical neurons
Shih-Han Kao, Shu-Yang Liang, Pei-Lin Cheng and Hsiung-Lin Tu*
Advanced Biology, 2022, 6 (6), 2101325. Can be read here: link https://doi.org/10.1002/adbi.202101325 |
Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry
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Sofani Gebreyesus,† Asad Siyal,† Reta Kitata, Eric Sheng-Wen Chen, Bayarmaa Enkhbayar, Takashi Angata, Kuo-I Lin, Yu-Ju Chen* and Hsiung-Lin Tu*
Nat. Comm., 2022, 13, 37. https://doi.org/10.1038/s41467-021-27778-4 |
Sample size-comparable spectral library enhances data-independent acquisition-based proteome coverage of low-input cells
Asad Siyal, Sheng-Wen Chen, Hsin-Ju Chan, Reta Kitata, Jhih-Ci Yang, Hsiung-Lin Tu and Yu-Ju Chen*,
Anal. Chem. 2021, 93, 17003–17011. https://doi.org/10.1021/acs.analchem.1c03477 |
Stable crystalline organic-inorganic hybrid Indium Phosphate with dye removal and ractopamine detection applications
Chu Wang , Jia-Rong Li, Ying Li, Hsiung-Lin Tu, Der-Lii Tzou and Chih-Min Wang*
Inorg. Chem. 2021, 60, 11655-11660. https://doi.org/10.1021/acs.inorgchem.1c01664 |
Multiplexed patterning of hybrid lipid membrane and protein arrays for cell signaling study
Yu-Ting Ti, Hsiao-Chi Cheng, Ying Li and Hsiung-Lin Tu*
Lab Chip, 2021, 21, 2711-2720 (Back Cover). https://doi.org/10.1039/D1LC00178G |
Construction of intracellular asymmetry and asymmetric division in Escherichia coli
Da-Wei Lin, Yang Liu, Yue-Qi Lee, Po-Jiun Yang, Chia-Tse Ho, Jui-Chung Hong, Jye-Chian Hsiao, Der-Chien Liao, An-Jou Liang, Tzu-Chiao Hung, Yu-Chuan Chen, Hsiung-Lin Tu, Chao-Ping Hsu and Hsiao-Chun Huang*
Nat. Comm., 2021, 12, 888. https://doi.org/10.1038/s41467-021-21135-1 |
NF-κB responds to absolute differences in cytokine concentrations
Minjun Son, Andrew Wang, Hsiung-Lin Tu, Marie Metzig, Parthiv Patel, Kabir Husain, Jing Lin, Arvind Murugan, Alexander Hoffmann and Savaş Tay*
Sci. Signal., 2021, 14, eaaz4382. https://doi.org/10.1126/scisignal.aaz4382 |
Highly sensitive detection of mercury ion using zincophosphite framework nanoparticle-polyaniline composites
Ying Li, Ji-Fang Xie, Chiao-Chun Chang, Chih-Min Wang* and Hsiung-Lin Tu*
ACS Applied Nano Materials, 2020, 3, 9724 (Supplementary Cover). https://doi.org/10.1021/acsanm.0c01837 |
A thio-functionalized zinc phosphite with a large-channel framework and enhanced removal ability of mercury ion from aqueous solutions
Jui Hsieh, Ju-Ying Chen, Han-Ying Li, Hsin-Kuan Liu, Hsiung-Lin Tu and Chih-Min Wang*
Dalton Trans., 2020, 49, 11085. https://doi.org/10.1039/D0DT02270E |
Mechanotactic activation of TGF‐β by PEDOT artificial microenvironments triggers epithelial to mesenchymal transition
Udesh Dhawana, Wei-Li Wang, Bhaskarchand Gautam, Jayakrishnan Janardhanan. Po-Chiang Hsiao, Hsiung-Lin Tu and Hsiao-Hua Yu*
Advanced Biosystems, 2020, 4, 1900165. https://doi.org/10.1002/adbi.201900165 |
Ultra-sensitive digital quantification of proteins and mRNA in single cells
Jing Lin, Christian Jordi, Minjun Son, Hoang Phan, N. Drayman, Mustafa Abasiyanik, Luke Vistain, Hsiung-Lin Tu and Savaş Tay*
Nat. Comm., 2019, 10, 3544. https://doi.org/10.1038/s41467-019-11531-z |
Ultra-multiplexed analysis of single cell dynamics reveals logic rules in differentiation
Ce Zhang, Hsiung-Lin Tu, Gengjie Jia, Tanzila Mukhtar, Verdon Taylor, Andrey Rzhetsky and Savaş Tay*
Science Advances, 2019, 5, eaav7959. https://doi.org/10.1126/sciadv.aav7959 |
Before joining IoC AS (-2018)
- S. Christensen†, H.-L Tu†, J. Jun†, S. Alvarez, M. Triplet, J. Iwig, K. Yadav, D. Bar-Sagi, J. Roose* and J. Groves*. One-way membrane trafficking of SOS in receptor- triggered Ras activation. Nat. Struct. Mol. Biol., 2016, 23, 838-846.
- W. Y.-C. Huang, Q. Yan, W.-C. Lin, J. Chung, S. Hansen, S. Christensen, H.-L. Tu, J. Kuriyan and J. Groves*. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc. Natl. Acad. Sci. 2016, 113, 8218-8223.
- S. Christensen, M. Triplet, C. Rhodes, J. Iwig, H.-L. Tu, D. Stamou and J. Groves*. Monitoring the waiting time sequence of single Ras GTPase activation events using liposome functionalized zero mode waveguides. Nano Lett., 2016, 16, 2890-2895.
- L. Iversen†, H.-L. Tu†,W.-C. Lin, S. Christensen, S. Abe, J. Iwig, H.-J. Wu, J. Gureasko, C. Rhodes, R. Petit, S. Hansen, P. Thill, C.-H. Yu, D. Stamou, A. Chakraborty, J. Kuriyan and J. Groves*. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics. Science, 2014, 345, 50-54.
- W.-C. Lin†, L. Iversen†, H.-L. Tu, C. Rhodes, S. Christensen, J. Iwig, S. Hansen, W. Y.-C. Huang and J. Groves*. H-Ras forms dimers on membrane surfaces via a protein-protein interface. Proc. Natl. Acad. Sci. 2014, 111, 2996-3001.
- T. Lohmüller, L. Iversen, M. Schmidt, C. Rhodes, H.-L. Tu, W.-C. Lin and J. Groves*. Single molecule tracking on supported membranes with arrays of optical nanoantennas. Nano Lett., 2012, 12, 1717-1721.
- H.-L. Tu, Y.-S. Lin, H.-Y. Lin, Y. Hung, L.-W. Lo, Y.-F. Chen and C.-Y. Mou*. In-vitro studies of functionalized mesoporous silica nanoparticles for photodynamic therapy. Adv. Mater., 2009, 21, 172-177.
- H.-L. Tu, F.-Y. Tsai and C.-Y. Mou* One step synthesis of ordered mesostructural organic/silica nanocomposite with tunable fluorescence surfactants. J. Mater. Chem., 2008, 18, 1771-1778.
- F.-Y. Tsai, H.-L. Tu and C.-Y. Mou*. Nonionic fluorescent oligomeric surfactant for ordered mesoporous silica structure. J. Mater. Chem., 2006, 16, 348-350.